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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
POLE2
All Species:
47.88
Human Site:
S59
Identified Species:
70.22
UniProt:
P56282
Number Species:
15
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P56282
NP_002683.2
527
59537
S59
V
E
K
Q
P
L
S
S
N
M
I
E
R
S
V
Chimpanzee
Pan troglodytes
XP_509931
527
59578
S59
V
E
K
Q
P
L
S
S
N
M
I
E
R
S
V
Rhesus Macaque
Macaca mulatta
XP_001095940
525
59213
S62
N
V
V
K
P
L
S
S
S
M
I
E
R
S
V
Dog
Lupus familis
XP_851216
527
59504
S59
V
E
K
Q
P
L
S
S
N
M
I
E
R
S
V
Cat
Felis silvestris
Mouse
Mus musculus
O54956
527
59368
S59
V
E
K
Q
P
L
S
S
N
M
I
E
R
S
V
Rat
Rattus norvegicus
XP_216727
527
59187
S59
V
E
K
Q
P
L
S
S
N
M
I
E
R
S
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515002
535
60459
S67
V
E
K
Q
P
L
S
S
N
M
I
E
R
S
V
Chicken
Gallus gallus
Q5ZKQ6
527
59609
T59
V
E
K
Q
P
L
S
T
N
M
I
E
L
S
T
Frog
Xenopus laevis
NP_001083783
527
59670
S59
V
E
K
Q
P
L
S
S
N
M
I
E
K
S
T
Zebra Danio
Brachydanio rerio
NP_775353
527
59243
S59
V
E
K
Q
P
L
S
S
S
M
V
D
L
C
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_647995
525
58740
T61
L
Q
S
Q
K
L
L
T
P
H
V
E
R
A
A
Honey Bee
Apis mellifera
XP_001120791
454
52119
L14
F
A
L
A
K
E
L
L
N
I
E
E
N
E
Q
Nematode Worm
Caenorhab. elegans
Q19196
534
60979
S63
L
K
K
Q
T
L
Q
S
S
L
I
S
E
E
L
Sea Urchin
Strong. purpuratus
XP_796825
501
56117
E53
C
S
D
G
G
K
E
E
N
E
K
M
F
N
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001147081
533
59891
S60
L
D
K
E
P
L
Q
S
S
I
L
D
R
D
A
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P24482
689
78322
A130
D
D
E
M
P
I
A
A
D
S
S
L
Q
N
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
92.4
93.5
N.A.
90.1
90.8
N.A.
86.1
82.1
81
73.2
N.A.
42.1
39.2
30.8
57.6
Protein Similarity:
100
99.2
94.3
97.1
N.A.
94.8
95.2
N.A.
90.8
91.4
91
88
N.A.
59.7
58
51.1
75.7
P-Site Identity:
100
100
66.6
100
N.A.
100
100
N.A.
100
80
86.6
66.6
N.A.
26.6
13.3
33.3
13.3
P-Site Similarity:
100
100
80
100
N.A.
100
100
N.A.
100
86.6
93.3
86.6
N.A.
60
20
66.6
20
Percent
Protein Identity:
N.A.
36.2
N.A.
N.A.
24.3
N.A.
Protein Similarity:
N.A.
56.2
N.A.
N.A.
42.9
N.A.
P-Site Identity:
N.A.
33.3
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
80
N.A.
N.A.
66.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
7
0
0
7
7
0
0
0
0
0
7
13
% A
% Cys:
7
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% C
% Asp:
7
13
7
0
0
0
0
0
7
0
0
13
0
7
0
% D
% Glu:
0
57
7
7
0
7
7
7
0
7
7
69
7
13
0
% E
% Phe:
7
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% F
% Gly:
0
0
0
7
7
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
7
0
0
0
13
63
0
0
0
0
% I
% Lys:
0
7
69
7
13
7
0
0
0
0
7
0
7
0
0
% K
% Leu:
19
0
7
0
0
82
13
7
0
7
7
7
13
0
7
% L
% Met:
0
0
0
7
0
0
0
0
0
63
0
7
0
0
0
% M
% Asn:
7
0
0
0
0
0
0
0
63
0
0
0
7
13
0
% N
% Pro:
0
0
0
0
75
0
0
0
7
0
0
0
0
0
0
% P
% Gln:
0
7
0
69
0
0
13
0
0
0
0
0
7
0
7
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
57
0
0
% R
% Ser:
0
7
7
0
0
0
63
69
25
7
7
7
0
57
0
% S
% Thr:
0
0
0
0
7
0
0
13
0
0
0
0
0
0
13
% T
% Val:
57
7
7
0
0
0
0
0
0
0
13
0
0
0
63
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _